Miguel Ángel Casado Combreras

Group: Biology and Genetic Engineering of Multicellular Cyanobacteria

Position: Postdoctoral researcher

Contact:

Lab LE113 (cicCartuja 1)

Phone number: +34 954 13 91 95 / ext. 446093

email:

Formation

BSc Pharmacy (University of Granada, 2015)

MSc Molecular Biology and Biotechnology (University of Granada, 2016)

PhD Biology (University of Seville, 2024)

Research Interests

My scientific career has focused on studying the structure and interactions of macromolecules, particularly their biophysical analysis, to understand their functionality within the cell from a structural perspective.

I have primarily studied highly dynamic protein-protein complexes, including those involving intrinsically disordered proteins engaged in biomolecular condensation, by integrating protein biochemistry, biophysics (particularly spectroscopic techniques), synthetic biology, microscopy, and computational biology.

Currently, I am looking into the molecular mechanisms that govern the organization and dynamics of biomolecular condensates, as well as their biotechnological applications in cyanobacteria, such as enzyme immobilization systems for developing bioremediation strategies.

Publications

Casado-Combreras MÁ, De la Rosa MA, Díaz-Moreno I (2025) Protocols for monitoring condensate formation and dynamics between the phase-separating proteins SET/TAF-Iβ and cytochrome c. STAR Protoc. 20: 103796.

Baños-Jaime B, Uceda-Mayo AB, Rivero-Rodríguez F, Casado-Combreras MÁ, Velázquez-Cruz A, Velázquez-Campoy A, Corrales-Guerrero L, De la Rosa MA, Díaz-Moreno I (2025) Evolutionary Pro-To-Thr mutation in the intrinsically disordered domain of ANP32 family members modulates their target binding modes. Adv Sci. 12: e2415566.

Casado-Combreras MÁ, Velázquez-Campoy A, Martinho M, Belle V, De la Rosa MA, Díaz-Moreno I (2024) Cytochrome c prompts the recruitment of its nuclear partners SET/TAF-Iβ and NPM1 into biomolecular condensates. iScience. 27: 110435.

González-Arzola K, Díaz-Quintana A, Bernardo-García N, Martínez-Fábregas J, Rivero-Rodríguez F, Casado-Combreras MÁ, Elena-Real CA, Velázquez-Cruz A, Gil-Caballero S, Velázquez-Campoy A, Szulc E, Gavilán MP, Ayala I, Arranz R, Ríos RM, Salvatella X, Valpuesta JM, Hermoso JA, De la Rosa MA, Díaz-Moreno I (2022) Nucleus-translocated mitochondrial cytochrome c liberates nucleophosmin-sequestered ARF tumor suppressor by changing nucleolar liquid-liquid phase separation. Nat Struct Mol Biol. 29:1024-1036. 10.1038/s41594-022-00842-3.

Casado-Combreras MÁ, Rivero-Rodríguez F, Elena-Real CA, Molodenskiy D, Díaz-Quintana A, Martinho M, Gerbaud G, González-Arzola K, Velázquez-Campoy A, Svergun D, Belle V, De la Rosa MA, Díaz-Moreno I (2022) PP2A is activated by cytochrome c upon formation of a diffuse encounter complex with SET/TAF-Iβ. Comput Struct Biotechnol J. 20: 3695-3707.