Juan Manuel Pérez Ruiz
Group: Redox signaling in plants
Position: Profesor Titular US
Contact:
Office: D214
Phone: (+34) 954139167 (ext. 446013)
email:
Formation
B.Sc. in Biology, Universidad de Sevilla (1999)
B.Sc. in Biochemistry, Universidad de Sevilla (2001)
Ph.D. Biochemistry, Universidad de Sevilla (2007)
Research Interests
My scientific career has focused on the study of the function of the chloroplast redox network in plant acclimation to environmental cues. Using Arabidopsis thaliana as a model system, we uncovered that redox homeostasis is achieved by the concerted action of NTRC and TRXs, functionally integrated by the activity of 2-Cys PRXs, redefining the classical chloroplast redox regulation model. At present, we investigate the roles of 2-Cys Prxs, dual-function enzymes acting as peroxidases and as molecular chaperones, in chloroplast biogenesis during seed and seedling development, which are critical stages of plant growth. Our short-term goal is to identify biotechnological targets for improving temperature stress tolerance in crops using Camelina sativa an oilseed plant of agronomic interest which is a close relative of Arabidopsis.
Publications
| Hernández ML, Jiménez-López J, Cejudo FJ, Pérez-Ruiz JM. 2-Cys peroxiredoxins contribute to thylakoid lipid unsaturation by affecting ω-3 fatty acid desaturase 8. Plant Physiol. 2024 May 31;195(2):1521-1535. doi: 10.1093/plphys/kiae102. PMID: 38386701; PMCID: PMC11142380. |
| Gallardo-Martínez AM, Jiménez-López J, Hernández ML, Pérez-Ruiz JM, Cejudo FJ. Plastid 2-Cys peroxiredoxins are essential for embryogenesis in Arabidopsis. Redox Biol. 2023 Jun;62:102645. doi: 10.1016/j.redox.2023.102645. Epub 2023 Mar 1. PMID: 36898225; PMCID: PMC10020101. |
| Ojeda V, Jiménez-López J, Romero-Campero FJ, Cejudo FJ, Pérez-Ruiz JM. A chloroplast redox relay adapts plastid metabolism to light and affects cytosolic protein quality control. Plant Physiol. 2021 Sep 4;187(1):88-102. doi: 10.1093/plphys/kiab246. PMID: 34618130; PMCID: PMC8418392. |
| Ojeda V, Pérez-Ruiz JM, Cejudo FJ. 2-Cys Peroxiredoxins Participate in the Oxidation of Chloroplast Enzymes in the Dark. Mol Plant. 2018 Nov 5;11(11):1377-1388. doi: 10.1016/j.molp.2018.09.005. Epub 2018 Oct 4. PMID: 30292682. |
| Pérez-Ruiz JM, Naranjo B, Ojeda V, Guinea M, Cejudo FJ. NTRC-dependent redox balance of 2-Cys peroxiredoxins is needed for optimal function of the photosynthetic apparatus. Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):12069-12074. doi: 10.1073/pnas.1706003114. Epub 2017 Oct 24. PMID: 29078290; PMCID: PMC5692536. |