Aurelio Serrano Delgado

Group: Environmental and epigenetic regulation of development in plants

Position: Investigador Científico CSIC (Senior Research Scientist)

Contact:

Laboratory: LS112 Office: D S120 tel. 954489524 tel. ext. 446024
email:

Formation

Degree in Biological Sciences, Excellent 1979

PhD in Biological Sciences, Excellent Cum Laude 1985

Postdoctoral Fellow CONICET, CEFOBI-Univ. Nac. de Rosario, Argentina 1985-86

Research Fellow Alexander von Humboldt Foundation, Univ. of Konstanz, Germany 1988-89

Researcher, Vienna Biocenter, Univ. Wien, Austria 1993(FEBS), 1995-97, 2001-02

Head of Research Group BIO261 (PAI) 1997-2024

Secretary General FEPS – Federation of European Protistological Societies 2011-2015

Research Interests

Inorganic pyrophosphate (PPi), a ubiquitous energy-rich metabolite like ATP, is the basis of an alternative bioenergetics specific to plants and many microorganisms in which membrane PPases play a key role, and constitutes an important adaptive advantage under conditions of chronic stress. PPi must also play a key role in other relevant biological processes such as cell proliferation and ageing. The role of phosphite and other reduced P compounds as nutrients for microalgae, already studied by our group, and as biostimulants for plants of agronomic interest is a topic with great biotechnological potential that deserves further study

6 six-year research periods (1980-2015) awarded by the Natl. Science Evaluation Agency (CNEAI)

8 five-year research-teaching-training-scientific dissemination activity periods (1980-2019) granted by the National Research Council (CSIC)

8 PhD theses supervised (1995-2017) one of them US Extraordinary Prize

Publications

Serrano A, Pérez-Castiñeira JR, Baltscheffsky M, Baltscheffsky H. H+-PPases: yesterday, today and tomorrow. IUBMB Life. 2007 Feb;59(2):76-83. doi: 10.1080/15216540701258132. PMID: 17454298.

Pérez-Castiñeira JR, Hernández A, Drake R, Serrano A. A plant proton-pumping inorganic pyrophosphatase functionally complements the vacuolar ATPase transport activity and confers bafilomycin resistance in yeast. Biochem J. 2011 Jul 15;437(2):269-78. doi: 10.1042/BJ20110447. PMID: 21612578.

Serrano-Bueno G, Hernández A, López-Lluch G, Pérez-Castiñeira JR, Navas P, Serrano A. Inorganic pyrophosphatase defects lead to cell cycle arrest and autophagic cell death through NAD+ depletion in fermenting yeast. J Biol Chem. 2013 May 3;288(18):13082-92. doi: 10.1074/jbc.M112.439349. Epub 2013 Mar 11. PMID: 23479727; PMCID: PMC3642350.

Albi T, Serrano A. Inorganic polyphosphate in the microbial world. Emerging roles for a multifaceted biopolymer. World J Microbiol Biotechnol. 2016 Feb;32(2):27. doi: 10.1007/s11274-015-1983-2. Epub 2016 Jan 9. PMID: 26748804.

Pérez-Castiñeira JR, Serrano A. The H⁺-Translocating Inorganic Pyrophosphatase From Arabidopsis thaliana Is More Sensitive to Sodium Than Its Na⁺-Translocating Counterpart From Methanosarcina mazei. Front Plant Sci. 2020 Aug 12;11:1240. doi: 10.3389/fpls.2020.01240. PMID: 32903538; PMCID: PMC7438732.