Manuel Jesús Mallén Ponce

Manuel Jesús Mallén Ponce

ORCID: 0000-0002-2312-313X

Group: TOR signaling and autophagy in microalgae

Position: Juan de la Cierva postdoctoral researcher

Contact:

Lab: LE111

Phone: ext. 446090

Mail:

Formation

Degree on Biochemistry, Universidad de Sevilla, 2013

Master of Science in Molecular Genetics and Biotechnology, Universidad de Sevilla, 2014

PhD on Biochemistry, Universidad de Sevilla, 2020

Margarita Salas postdoctoral researcher, Institut de Biologie Paris-Seine (Sorbonne Université-CNRS), Paris (France), 2022

Research Interests

My research interests focus on nutrient regulation of the kinase TOR (target of rapamycin) in photosynthetic organisms. TOR balances the synthesis and degradation of proteins, lipids, carbohydrates or nucleic acids in response to nutrients and cellular energy to promote cell growth. The main objective is to identify and understand the nutrient signals that control TOR activity using the microalga Chlamydomonas reinhardtii as a model organism.

Publications

Pérez-Pérez ME1, Mallén-Ponce MJ1, Odriozola-Gil Y, Rubio A, Salas JJ, Martínez-Force E, Pérez-Pulido AJ, Crespo JL. Lipid turnover through lipophagy in the newly identified extremophilic green microalga Chlamydomonas urium. New Phytol. 2024 Jul;243(1):284-298. doi: 10.1111/nph.19811.
Mallén-Ponce MJ, Pérez-Pérez ME. Redox-mediated activation of ATG3 promotes ATG8 lipidation and autophagy progression in Chlamydomonas reinhardtii. Plant Physiol. 2023 Dec 30;194(1):359-375. doi: 10.1093/plphys/kiad520.
Mallén-Ponce MJ, Florencio FJ, Huertas MJ. Thioredoxin A regulates protein synthesis to maintain carbon and nitrogen partitioning in cyanobacteria. Plant Physiol. 2024 Feb 22:kiae101. do:10.1093/plphys/kiae101.
Mallén-Ponce MJ, Pérez-Pérez ME, Crespo JL. Photosynthetic assimilation of CO2 regulates TOR activity. Proc Natl Acad Sci U S A. 2022 Jan 11;119(2):e2115261119. doi: 10.1073/pnas.2115261119.
Mallén-Ponce MJ, Huertas MJ, Sánchez-Riego AM, Florencio FJ. Depletion of m-type thioredoxin impairs photosynthesis, carbon fixation, and oxidative stress in cyanobacteria. Plant Physiol. 2021 Nov 3;187(3):1325-1340. doi: 10.1093/plphys/kiab321.
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