Laura Corrales Guerrero

Group: Biology and Genetic Engineering of Multicellular Cyanobacteria

Position: Ramón y Cajal Researcher

Contact:

Office: DS121

Telephone: (+34) 954489640

E-mail:

Formation

Academic formation:

BSc Biology, Universidad de Sevilla, 2008

PhD Biology, Universidad de Sevilla, 2014

Projects running:

ecoPHLAstics: Innovative technology for the immobilization of enzymatic cascades into Biomolecular Condensates (RYC2023-042841-I)

CyanoCon: Biomolecular Condensates in Cyanobacteria to produce biodegradable Bioplastics (PID2023-146704OA-I00)

PHLAG: Generation and characterization of synthetic enzymatic organelles (CNS2024-154839)

Research Interests

My research interests have been very broad, from cell differentiation and cell division in cyanobacteria and alphaproteobacteria, to biomolecular condensates formation across different domains of life. I have investigated protein interactions and dynamics, specializing in protein-protein and protein-nucleic acid interactions. My work integrates advanced microscopy, genetics, protein biochemistry, biophysical methods and synthetic biology to uncover new insights into cellular processes and their biotechnological applications.

As an independent researcher, my current scientific focus is to deepen our understanding of the molecular mechanisms governing biomolecular condensates and to explore their potential uses in biotechnology, specifically for cyanobacteria, as enzymatic immobilization systems and in bioremediation.

Publications

Baños-Jaime B, Corrales-Guerrero L, Pérez-Mejías G, Rejano-Gordillo CM, Velázquez-Campoy A, Martínez-Cruz LA, Martínez-Chantar ML, De la Rosa MA, Díaz-Moreno I. Phosphorylation at the disordered N-end makes HuR accumulate and dimerize in the cytoplasm. Nucleic Acids Res. 2024 Jul 5:gkae564. doi: 10.1093/nar/gkae564. Epub ahead of print. PMID: 38966993.
West DL, Loughlin FE, Rivero-Rodríguez F, Vankadari N, Velázquez-Cruz A, Corrales-Guerrero L, Díaz-Moreno I, Wilce JA. Regulation of TIA-1 Condensates: Zn2+ and RGG Motifs Promote Nucleic Acid Driven LLPS and Inhibit Irreversible Aggregation. Front Mol Biosci. 2022 Jul 14;9:960806. doi: 10.3389/fmolb.2022.960806. PMID: 35911965; PMCID: PMC9329571.
Corrales-Guerrero L, Steinchen W, Ramm B, Mücksch J, Rosum J, Refes Y, Heimerl T, Bange G, Schwille P, Thanbichler M. MipZ caps the plus-end of FtsZ polymers to promote their rapid disassembly. Proc Natl Acad Sci U S A. 2022 Dec 13;119(50):e2208227119. doi: 10.1073/pnas.2208227119. Epub 2022 Dec 9. PMID: 36490318; PMCID: PMC9897490.
Corrales-Guerrero L, He B, Refes Y, Panis G, Bange G, Viollier PH, Steinchen W, Thanbichler M. Molecular architecture of the DNA-binding sites of the P-loop ATPases MipZ and ParA from Caulobacter crescentus. Nucleic Acids Res. 2020 May 21;48(9):4769-4779. doi: 10.1093/nar/gkaa192. PMID: 32232335; PMCID: PMC7229837.
Corrales-Guerrero L, Mariscal V, Flores E, Herrero A. Functional dissection and evidence for intercellular transfer of the heterocyst-differentiation PatS morphogen. Mol Microbiol. 2013 Jun;88(6):1093-105. doi: 10.1111/mmi.12244. Epub 2013 May 13. PMID: 23663167.
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