José Luis Crespo González

José Luis Crespo González

ORCID: 0000-0003-3514-1025

Group: TOR signaling and autophagy in microalgae

Position: Investigador Científico CSIC

Contact:

Office DE108


tel. ext. 446074


email:

Formation

Grade in Biology, University of Sevilla, 1993

PhD in Biology, University of Sevilla, 1999

FEBS postdoctoral researcher, Biozentrum, Mike Hall lab, University of Basel, (Switzerland), 1999-2003

EMBO Visiting scholar, University of Geneva (Switzerland), Jean-David Rochaix lab, April-June 2003

Research Interests

TOR (target of rapamycin) is a central regulator of cell growth that responds to nutrient availability. TOR is highly conserved in all eukaryotes, including the green lineage. My research is focused on studying the regulation of TOR signaling in photosynthetic organisms by using microalgae as model system.

Our group investigates the regulation of TOR activity by nutritional inputs, as well as different cellular processes controlled by the TOR pathway, using the model microalga Chlamydomonas reinhardtii and the extremophilic microalga Chlamydomonas urium.

Our specific objectives are:

  • Unravel the regulation of TOR activity by nutrients.
  • Identification of TOR-interacting proteins in photosynthetic organisms.
  • Analysis of cellular processes regulated by the TOR pathway.

Publications

  1. Pérez-Pérez ME, Mallén-Ponce MJ, Odriozola-Gil Y, Rubio A, Salas JJ, Martínez-Force E, Pérez-Pulido AJ, Crespo JL. Lipid turnover through lipophagy in the newly identified extremophilic green microalga Chlamydomonas urium. New Phytol. 2024 Jul;243(1):284-298. https://doi.org/10.1111/nph.19811
  2. Mallén-Ponce MJ, Pérez-Pérez ME, Crespo JL. Analyzing the impact of autotrophic and heterotrophic metabolism on the nutrient regulation of TOR. New Phytol. 2022 Nov;236(4):1261-1266. https://doi.org/10.1111/nph.18450
  3. Mallén-Ponce MJ, Pérez-Pérez ME, Crespo JL. Photosynthetic assimilation of CO2 regulates TOR activity. Proc Natl Acad Sci U S A. 2022 Jan 11;119(2):e2115261119. https://doi.org/10.1073/pnas.2115261119
  4. Couso I, Pérez-Pérez ME, Ford MM, Martínez-Force E, Hicks LM, Umen JG, Crespo JL. Phosphorus Availability Regulates TORC1 Signaling via LST8 in Chlamydomonas. Plant Cell. 2020 Jan;32(1):69-80. https://doi.org/10.1105/tpc.19.00179
  5. Crespo JL, Powers T, Fowler B, Hall MN. The TOR-controlled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine. Proc Natl Acad Sci U S A. 2002 May 14;99(10):6784-9. https://doi.org/10.1073/pnas.102687599
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