Angeles Aroca Aguilar

Formation

2008    PhD degree at Department of Biotechnology and Genetic resources in plants, ETSI Agricultural, Polytechnic University of Madrid, Spain.

2009-2019      Postdoc at different centres: Department of Plant Biochemistry and Molecular Biology. (University of Seville), NMR Swedish Centre, (Goteborg, Sweden), Cysteine Biosynthesis and Metabolic Networks Research Group (IBVF-CSIC, Sevilla), Institut de Biochimie et Genetique Cellulaires (CNRS), (Bordeaux, France.), MSCA-IF-GF at Iowa State University (Iowa, USA).

2021    Associate professor at University of Seville (Spain)

Research Interests

My postdoctoral research career during the last 10 years has been focused on the study of post-translational modifications of cysteine, especially persulfidation. I have applied state-of-the-art techniques and technology focused mainly on the proteomic analysis of the physiological effects of sulfide on molecular targets regulated by these post-translational modifications. In this regard, three fundamental milestones I have addressed during this research include: a) elucidate the mechanism of action of sulfide in plants through a new post-translational modification of proteins named persulfidation; b) decipher wide range of action of persulfidation in diverse biological processes and c) describe a new regulation mechanism of bulk and selective autophagy through sulfide in Arabidopsis, which constituted the first time cited that sulfide regulates autophagy in a eukaryotic organism.

Publications

  • Aroca Á, Serna A, Gotor C, Romero LC. S-sulfhydration: a cysteine posttranslational modification in plant systems. Plant Physiol. 2015 May;168(1):334-42. doi: 10.1104/pp.15.00009. Epub 2015 Mar 25. PMID: 25810097; PMCID: PMC4424021.
  • Aroca A, Benito JM, Gotor C, Romero LC. Persulfidation proteome reveals the regulation of protein function by hydrogen sulfide in diverse biological processes in Arabidopsis. J Exp Bot. 2017 Oct 13;68(17):4915-4927. doi: 10.1093/jxb/erx294. PMID: 28992305; PMCID: PMC5853657.
  • Laureano-Marín AM*, Aroca Á*, Pérez-Pérez ME, Yruela I, Jurado-Flores A, Moreno I, Crespo JL, Romero LC, Gotor C. Abscisic Acid-Triggered Persulfidation of the Cys Protease ATG4 Mediates Regulation of Autophagy by Sulfide. Plant Cell. 2020 Dec;32(12):3902-3920. doi: 10.1105/tpc.20.00766. Epub 2020 Oct 9. PMID: 33037147; PMCID: PMC7721334. * These authors contributed equally to this work.
  • Aroca A, Yruela I, Gotor C, Bassham DC. Persulfidation of ATG18a regulates autophagy under ER stress in Arabidopsis. Proc Natl Acad Sci U S A. 2021 May 18;118(20):e2023604118. doi: 10.1073/pnas.2023604118. PMID: 33975948; PMCID: PMC8157962. Aroca A is corresponding author.
  • García-Calderón M, Vignane T, Filipovic MR, Ruiz MT, Romero LC, Márquez AJ, Gotor C, Aroca A. Persulfidation protects from oxidative stress under nonphotorespiratory conditions in Arabidopsis. New Phytol. 2023 May;238(4):1431-1445. doi: 10.1111/nph.18838. Epub 2023 Mar 18. PMID: 36840421. Aroca A is corresponding author.
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