Our group has been pioneer in the study of the target of rapamycin (TOR) signaling pathway and autophagy, a degradative process conserved in all eukaryotes required for the cellular adaptation to stress, in the model unicellular green alga Chlamydomonas reinhardtii. The main goal of our research is to understand how stress, in particular redox unbalance, regulates autophagy in photosynthetic eukaryotes using Chlamydomonas as model system. We have unraveled the molecular mechanisms underlying the redox regulation of some key components of the autophagic machinery in Chlamydomonas. Future research lines will investigate the complex regulation of autophagy by environmental stress and the role of the TOR signaling pathway in the control of this degradative process.
Collaborators
Stephane Lemaire (CNRS, Paris, France)
Jean-David Rochaix (University of Geneva)
Michael Schroda (TU Kaiserslautern, Germany)
Sabeeha Merchant (University of California, USA)
Cecilia Gotor/Luis Carlos Romero (IBVF, Sevilla)
Pilar Sánchez Testillano (CIB, CSIC, Madrid)
1) Redox control of autophagy
2) Control of autophagy by TOR
• Plan Nacional (BFU2015-68216-P), Ministerio de Economía y Competitividad.
• Plan Nacional (BIO2015-74432-JIN), Ministerio de Economía y Competitividad.
• Proyecto ComFuturo (OTR02178), Fundación General del CSIC
• H2020 Marie Curie (reSGulating), European Union
• H2020 Marie Curie (INSPirAUTOR), European Union
• Korea Research Institute of Bioscience and Biotechnology (KRIBB): Molecular mechanism of autophagy in algae and its application in algal fuels.
Publicaciones destacadas
Publicaciones en revistas
Birth of a Photosynthetic Chassis: A MoClo Toolkit Enabling Synthetic Biology in the Microalga Chlamydomonas reinhardtii
Crozet, P., Navarro, F.J., Willmund, F., Mehrshahi, P., Bakowski, K., Lauersen, K.J., Pérez-Pérez, M.E., Auroy, P., Gorchs Rovira, A., Sauret-Gueto, S., Niemeyer, J., Spaniol, B., Theis, J., Trösch, R., Westrich, L.D., Vavitsas, K., Baier, T., Hübner, W., de Carpentier, F., Cassarini, M., Danon, A., Henri, J., Marchand, C.H., de Mia, M., Sarkissian, K., Baulcombe, D.C., Peltier G, Crespo, J.L., Kruse, O., Jensen, P.E., Schroda, M., Smith, A.G., Lemaire, S.D.
2018
ACS Synth Biol.
doi: 10.1021/acssynbio.8b00251
Publicaciones en revistas
Chloroplast damage induced by the inhibition of fatty acid synthesis triggers autophagy in Chlamydomonas
Heredia-Martinez, L.G., Andres-Garrido, A., Martinez-Force, E., Perez-Perez, M.E., Crespo, J.L.
