(L1G3) TOR signaling in Chlamydomonas

Control of autophagy by oxidative stress in the model green alga Chlamydomonas reinhardtii

Responsable: 
Institución: 
CSIC
Vigencia: 
01/01/2011 - 31/12/2011
Dotación: 
12.300
Referencia: 
2010FR0035

The role of TOR in autophagy regulation from yeast to plants and mammals

Autores: 
Díaz-Troya, S., Pérez-Pérez, M.E., Florencio, F.J., and Crespo, J.L.
Revista: 
Autophagy
Año Publicación: 
2008
Volumen: 
4
Páginas: 
851-865
Imagen: 

Target of rapamycin and LST8 proteins associate with membranes from the endoplasmic reticulum in the unicellular green alga Chlamydomonas reinhardtii

Autores: 
Díaz-Troya, S., Florencio, F.J. and Crespo, J.L.
Revista: 
Eukaryot Cell
Año Publicación: 
2008
Volumen: 
7
Páginas: 
212-222
Imagen: 

José Luis

Professional: 
Tenured Scientist (CSIC)
Email: 
crespo [at] ibvf [dot] csic [dot] es
Phone Extension: 
954489574

Cell signaling in Chlamydomonas

Summary

Our group has been pioneer in the study of the target of rapamycin (TOR) signaling pathway and autophagy, a degradative process conserved in all eukaryotes required for the cellular adaptation to stress, in the model unicellular green alga Chlamydomonas reinhardtii. The main goal of our research is to understand how stress, in particular redox unbalance, regulates autophagy in photosynthetic eukaryotes using Chlamydomonas as model system. We have unraveled the molecular mechanisms underlying the redox regulation of some key components of the autophagic machinery in Chlamydomonas. Future research lines will investigate the complex regulation of autophagy by environmental stress and the role of the TOR signaling pathway in the control of this degradative process.

Collaborators

Stephane Lemaire (CNRS, Paris, France)
Jean-David Rochaix (University of Geneva)
Michael Schroda (TU Kaiserslautern, Germany)
Sabeeha Merchant (University of California, USA)
Cecilia Gotor/Luis Carlos Romero (IBVF, Sevilla)
Pilar Sánchez Testillano (CIB, CSIC, Madrid)

1) Redox control of autophagy

2) Control of autophagy by TOR

• Plan Nacional (BFU2015-68216-P), Ministerio de Economía y Competitividad.
• Plan Nacional (BIO2015-74432-JIN), Ministerio de Economía y Competitividad.
• Proyecto ComFuturo (OTR02178), Fundación General del CSIC
• H2020 Marie Curie (reSGulating), European Union
• H2020 Marie Curie (INSPirAUTOR), European Union
• Korea Research Institute of Bioscience and Biotechnology (KRIBB): Molecular mechanism of autophagy in algae and its application in algal fuels.

Selected Publications
Type: Publications in journals
Birth of a Photosynthetic Chassis: A MoClo Toolkit Enabling Synthetic Biology in the Microalga Chlamydomonas reinhardtii
Authors: Crozet, P., Navarro, F.J., Willmund, F., Mehrshahi, P., Bakowski, K., Lauersen, K.J., Pérez-Pérez, M.E., Auroy, P., Gorchs Rovira, A., Sauret-Gueto, S., Niemeyer, J., Spaniol, B., Theis, J., Trösch, R., Westrich, L.D., Vavitsas, K., Baier, T., Hübner, W., de Carpentier, F., Cassarini, M., Danon, A., Henri, J., Marchand, C.H., de Mia, M., Sarkissian, K., Baulcombe, D.C., Peltier G, Crespo, J.L., Kruse, O., Jensen, P.E., Schroda, M., Smith, A.G., Lemaire, S.D.
Publication Year: 2018
Journal: ACS Synth Biol.
Volume: doi: 10.1021/acssynbio.8b00251
Type: Publications in journals
Chloroplast damage induced by the inhibition of fatty acid synthesis triggers autophagy in Chlamydomonas
Authors: Heredia-Martinez, L.G., Andres-Garrido, A., Martinez-Force, E., Perez-Perez, M.E., Crespo, J.L.
Publication Year: 2018
Journal: Plant Physiol.
Volume: DOI:10.1104/pp.18.00630

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